About: Tacrolimus [drugbank:DB00864]   Goto Sponge  NotDistinct  Permalink

An Entity of Type : http://bio2rdf.org/drugbank_vocabulary:Small-molecule, within Data Space : localhost:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tacrolimus [drugbank:DB00864]
rdfs:seeAlso
sameAs
dcterms:title
  • Tacrolimus
dcterms:description
  • Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
dcterms:identifier
  • drugbank:DB00864
void:inDataset
Bio2RDF identifier
  • DB00864
Bio2RDF namespace
  • drugbank
Bio2RDF uri
identifiers.org URI
x pdb [drugbank_vocabulary:x-pdb]
x pubchemcompound ...-pubchemcompound]
x pubchemsubstance...pubchemsubstance]
absorption [drugba...ulary:absorption]
affected organism ...ffected-organism]
calculated propert...lated-properties]
carrier [drugbank_vocabulary:carrier]
clearance [drugban...bulary:clearance]
dosage [drugbank_vocabulary:dosage]
drug classificatio...ication-category]
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